报告题目：Folding the genome by cohesin
报告人：于洪涛  教授 
主持人：汪方炜  教授
时   间：2021年10月14日（周四）下午4点
地   点：校友楼紫金港厅
报告人简介：

Professor Hongtao Yu received his B.S. in Chemistry from Peking University in 1990, and received his Ph.D. in Chemistry from Harvard University in 1995. He then completed his postdoctoral training at Harvard Medical School. Prof. Yu began his independent research career in 1999 as Assistant Professor in Department of Pharmacology at University of Texas Southwestern Medical Center. He was promoted to Associate Professor with tenure in 2004 and to Professor in 2008. From 2008-2019, he was appointed Howard Hughes Medical Institute (HHMI) Investigator. He was the holder of the Serena S. Simmons Distinguished Chair in Cancer Immunopharmacology before joining the faculty of Westlake University in December, 2019.

Abstract:

Human chromosomes, if linearly stitched together, span a length of over 2 meters. They need to be properly folded to be housed in the cell nucleus with a diameter of 10 µm. Chromosome folding also occurs in a dynamic, structured way that regulates gene expression, and DNA replication and repair. Initially discovered as the molecular glue that holds sister chromatids for segregation, the cohesin complex has recently been shown to be critical for structured chromosome folding. Cohesin organizes the genome by a process termed loop extrusion. Recent progress on the mechanism and function of cohesin in genome organization will be discussed.